Document Detail


Successful use of danaparoid in treatment of heparin-induced thrombocytopenia during twin pregnancy.
MedLine Citation:
PMID:  11770579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The treatment of heparin-induced thrombocytopenia in pregnancy is uncertain. Warfarin is contraindicated and ancrod is of unknown safety. Low-molecular-weight heparin should not be used because of cross-reactivity with unfractionated heparin. We report a case of heparin-induced thrombocytopenia during pregnancy treated successfully with danaparoid. CASE: A 25-year-old woman pregnant with twins developed heparin-induced thrombocytopenia after starting heparin therapy for a deep vein thrombosis. Treatment was initiated with danaparoid by subcutaneous injection and was continued until the time of delivery. Treatment was completed with 6 weeks of warfarin therapy postpartum. No fetal or maternal ill effects were observed. CONCLUSION: Danaparoid, which has low cross-reactivity for heparin-dependent antibodies and no known fetopathic effects, was used successfully to treat our patient, who developed heparin-induced thrombocytopenia during pregnancy. Danaparoid may be the treatment of choice for this difficult clinical situation in which there are limited therapeutic options.
Authors:
J Gill; M J Kovacs
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  90     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  2001-12-27     Completed Date:  2002-01-14     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  648-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Western Ontario, London, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / adverse effects*,  therapeutic use
Chondroitin Sulfates / therapeutic use*
Dermatan Sulfate / therapeutic use*
Drug Combinations
Female
Heparin / adverse effects*,  therapeutic use
Heparinoids / therapeutic use*
Heparitin Sulfate / therapeutic use*
Humans
Pregnancy
Pregnancy Complications, Hematologic / drug therapy*
Pregnancy, Multiple / blood*
Thrombocytopenia / chemically induced*,  drug therapy*
Twins
Venous Thrombosis / drug therapy*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Drug Combinations; 0/Heparinoids; 24967-94-0/Dermatan Sulfate; 83513-48-8/danaproid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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