| Successful use of danaparoid in treatment of heparin-induced thrombocytopenia during twin pregnancy. | |
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MedLine Citation:
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PMID: 11770579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The treatment of heparin-induced thrombocytopenia in pregnancy is uncertain. Warfarin is contraindicated and ancrod is of unknown safety. Low-molecular-weight heparin should not be used because of cross-reactivity with unfractionated heparin. We report a case of heparin-induced thrombocytopenia during pregnancy treated successfully with danaparoid. CASE: A 25-year-old woman pregnant with twins developed heparin-induced thrombocytopenia after starting heparin therapy for a deep vein thrombosis. Treatment was initiated with danaparoid by subcutaneous injection and was continued until the time of delivery. Treatment was completed with 6 weeks of warfarin therapy postpartum. No fetal or maternal ill effects were observed. CONCLUSION: Danaparoid, which has low cross-reactivity for heparin-dependent antibodies and no known fetopathic effects, was used successfully to treat our patient, who developed heparin-induced thrombocytopenia during pregnancy. Danaparoid may be the treatment of choice for this difficult clinical situation in which there are limited therapeutic options. |
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Authors:
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J Gill; M J Kovacs |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 90 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1997 Oct |
Date Detail:
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Created Date: 2001-12-27 Completed Date: 2002-01-14 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 648-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / adverse effects*, therapeutic use Chondroitin Sulfates / therapeutic use* Dermatan Sulfate / therapeutic use* Drug Combinations Female Heparin / adverse effects*, therapeutic use Heparinoids / therapeutic use* Heparitin Sulfate / therapeutic use* Humans Pregnancy Pregnancy Complications, Hematologic / drug therapy* Pregnancy, Multiple / blood* Thrombocytopenia / chemically induced*, drug therapy* Twins Venous Thrombosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Drug Combinations; 0/Heparinoids; 24967-94-0/Dermatan Sulfate; 83513-48-8/danaproid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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