| Successful urokinase treatment of massive pulmonary embolism in pregnancy. | |
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MedLine Citation:
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PMID: 7675404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thrombolytic agents have been used successfully to treat patients with massive pulmonary embolism and cardiorespiratory insufficiency, but experience with these drugs in pregnancy is limited. CASE: A 20-year-old woman at 21 weeks' gestation was admitted with a massive pulmonary embolism. She was initially given intravenous heparin therapy but because of worsening clinical condition, urokinase was used. After two 12-hour periods of therapy, the urokinase was discontinued and the heparin restarted. She remained on subcutaneous heparin therapy for the remainder of her pregnancy, which was otherwise uncomplicated. She delivered a healthy male infant at term without complications and was discharged on warfarin therapy. CONCLUSION: Thrombolytic therapy can be life-saving and should be considered in the treatment of hemodynamically significant pulmonary embolism in pregnancy. |
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Authors:
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W B Kramer; M Belfort; G R Saade; S Surani; K J Moise |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 86 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-10-19 Completed Date: 1995-10-19 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 660-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Pulmonary Embolism / drug therapy* Remission Induction Urokinase-Type Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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