| Successful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy? | |
| | |
MedLine Citation:
|
PMID: 19481029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pulmonary arterial hypertension (PAH) is a life-threatening disease of the pulmonary arterioles, which, in the absence of effective therapy, progresses rapidly to right heart failure and death. Opening of a patent foramen ovale (PFO) is common in patients with severe pulmonary hypertension (PH), resulting in resistive hypoxemia. We report the case of a 40-year-old woman with idiopathic pulmonary hypertension (iPAH) in New York Heart Association (NYHA) class III to IV, who was admitted in the intensive care unit with hemodynamic compromise and severe hypoxemia due to right-to-left shunt throughout a PFO. Combination therapy initially with inhaled iloprost and sildenafil, and then addition of an endothelin A receptor-selective antagonist (sitaxsentan), resulted in impressive improvement in oxygenation with reversal of the right-to-left shunt and marked improvement in functional class of the patient. |
| | |
Authors:
|
Georgia G Pitsiou; Nikolaos Chavouzis; Chrysanthi Nakou; Afroditi K Boutou; Paraskevi Argyropoulou; Ioannis Stanopoulos |
Related Documents
:
|
16198969 - Sudden death with clinically undiagnosed pulmonary hypertension. 2608319 - Acute effect of molsidomine on pulmonary circulation of patients with chronic obstructi... 11797939 - Activity of glutathione-s-transferase, gammaglutamiltransferase and catalase in the ery... 11936539 - Pulmonary hypertension in collagen vascular disease. 6437349 - The lupus anticoagulant, pulmonary thromboembolism, and fatal pulmonary hypertension. 8888969 - Tunica media remodeling in mesenteric arteries of hypertensive rats. 19725849 - Valvular heart disease in osteogenesis imperfecta: presentation of a case and review of... 3899649 - Diagnosis of tricuspid regurgitation. sensitivity of doppler ultrasound compared with c... 15282459 - Total aortic arch replacement with a branched graft and limited circulatory arrest of t... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 28 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-01 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
|
Languages: eng Pagination: 651-3 Citation Subset: IM |
Affiliation:
|
Respiratory Failure Unit, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antihypertensive Agents / therapeutic use Drug Therapy, Combination Epoprostenol / therapeutic use* Female Foramen Ovale, Patent / complications, diagnosis, drug therapy* Humans Hypertension, Pulmonary / complications, diagnosis, drug therapy* Iloprost / therapeutic use* Isoxazoles / therapeutic use* Piperazines / therapeutic use* Purines / therapeutic use Receptor, Endothelin A / antagonists & inhibitors Sulfones / therapeutic use* Thiophenes / therapeutic use* Treatment Outcome Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Isoxazoles; 0/Piperazines; 0/Purines; 0/Receptor, Endothelin A; 0/Sulfones; 0/Thiophenes; 0/Vasodilator Agents; 0/sitaxsentan; 139755-83-2/sildenafil; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reversible loss of pre-excitation as a sign of acute cardiac rejection.
Next Document: Vaccines and vaccination: the principles and the polemics.