| Successful unrelated BMT in a patient with Kostmann syndrome complicated by pre-transplant pulmonary 'bacterial' abscesses. | |
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MedLine Citation:
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PMID: 11571517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kostmann syndrome, severe congenital neutropenia, is often associated with life-threatening bacterial infections. A 5-year-old girl with Kostmann syndrome developed pulmonary abscesses. She was refractory to granulocyte colony-stimulating factor and antibiotics. She underwent unrelated HLA-matched BMT. Myeloablative conditioning consisted of 12-Gy TBI with lung shielding, antithymocyte globulin, etoposide, and cyclophosphamide. After successful engraftment, the pulmonary abscesses resolved by day 75 post-transplant. Although the option of transplantation is not established in the setting of unrelated HLA-matched BMT in Kostmann syndrome, this case may provide useful information. Furthermore, pre-transplant pulmonary bacterial abscesses may not be a contraindication for BMT in some patients with Kostmann syndrome. |
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Authors:
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H Toyoda; E Azuma; H Hori; M Hirayama; M Kobayashi; K Isogai; N Kondo; Y Komada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 28 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-25 Completed Date: 2001-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 413-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Tsu, Mie, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow Transplantation
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methods* Child, Preschool Female Humans Lung Abscess / complications*, microbiology* Methicillin Resistance Neutropenia / complications*, congenital, therapy* Staphylococcal Infections / complications* Syndrome Transplantation Conditioning Transplantation, Homologous |
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