| Successful trimethoprim-sulfamethoxazole therapy in a patient with hyperimmunoglobulin E syndrome. | |
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MedLine Citation:
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PMID: 8495097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A male patient with hyperimmunoglobulin E syndrome is described. Recurrent lymphadenitis and cutaneous staphylococcal abscesses were resistant to various antibiotics, and chemotaxis and hydrogen peroxide production of polymorphonuclear leukocytes were impaired. Following trimethoprim-sulfamethoxazole therapy, he was free from the above infections, and impaired polymorphonuclear leukocyte functions recovered and serum IgE decreased to approximately one-fifth of its initial level. Subsequent irregular medications, however, resulted in impairment of polymorphonuclear leukocyte functions and an increased serum IgE concentration, which recovered after regular resumption of trimethoprim-sulfamethoxazole treatment. From these results, the beneficial effects of trimethoprim-sulfamethoxazole in hyperimmunoglobulin E syndrome are clinically apparent, but in vitro studies failed to demonstrate the positive effect of trimethoprim-sulfamethoxazole on polymorphonuclear leukocytes and their mechanism still remains to be elucidated. |
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Authors:
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K Hattori; M Hasui; K Masuda; M Masuda; H Ogino; Y Kobayashi |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 82 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-06-24 Completed Date: 1993-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 324-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kansai Medical University, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Humans Immunoglobulin E / blood, drug effects Job's Syndrome / diagnosis, drug therapy* Male Neutrophils / drug effects Treatment Outcome Trimethoprim-Sulfamethoxazole Combination / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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