| Successful treatment with sodium valproate of a patient with Cushing's disease and gross enlargement of the pituitary. | |
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MedLine Citation:
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PMID: 6097074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transfrontal hypophysectomy was performed in a patient with Cushing's disease and gross enlargement of the pituitary. Despite some reduction of cortisol production active Cushing's syndrome remained due to the presence of a tumour remnant. Medical treatment with the GABA-transaminase inhibitor sodium valproate induced hypocorticism necessitating corticosteroid substitution therapy. Nine months after sodium valproate withdrawal hypercorticism was documented. Re-institution of sodium valproate treatment induced hypocorticism again. As sodium valproate is known to induce a decrease of plasma ACTH in Nelson's syndrome, it is proposed that large tumours present at the time of diagnosis and those appearing after adrenalectomy may represent the spectrum of a single disorder. A prospective trial to study the effects of sodium valproate and other neurotransmitter modulating agents on the size and endocrine function of ACTH secreting macroadenomas is urgently needed. |
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Authors:
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H P Koppeschaar; R J Croughs; J W van't Verlaat; M J Hendriks; C J Arts; J H Thijssen; F Schwarz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 107 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-14 Completed Date: 1985-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 471-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-Hydroxycorticosteroids
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urine Adenoma / blood, complications* Adrenocorticotropic Hormone / blood Cushing Syndrome / blood, complications, drug therapy* Female Humans Hydrocortisone / blood Middle Aged Pituitary Neoplasms / blood, complications* Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/17-Hydroxycorticosteroids; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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