| Successful treatment with rituximab of refractory idiopathic thrombocytopenic purpura in a patient with Kabuki syndrome. | |
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MedLine Citation:
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PMID: 19662467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kabuki syndrome (KS) is often associated with autoimmune abnormalities, such as idiopathic thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, leukoplakia and thyroiditis, as well as congenital anomalies. We herein present a KS patient with refractory ITP who achieved durable and complete remission in response to a total of four once-monthly infusions of rituximab. KS patients are often more susceptible to infection, so splenectomy should be avoided. Therefore, rituximab therapy is an alternative option for KS patients with ITP who fail to respond to first-line therapy. |
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Authors:
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Yuka Torii; Hiroshi Yagasaki; Hidenori Tanaka; Seiji Mizuno; Nobuhiro Nishio; Hideki Muramatsu; Asahito Hama; Yoshiyuki Takahashi; Seiji Kojima |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-07 |
Journal Detail:
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Title: International journal of hematology Volume: 90 ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-24 Completed Date: 2009-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 174-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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blood,
immunology* Antibodies, Monoclonal / administration & dosage* Child, Preschool Humans Immunologic Factors / administration & dosage* Male Platelet Count Purpura, Thrombocytopenic, Idiopathic / drug therapy*, immunology* Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunologic Factors; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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