Document Detail

Successful treatment with methylprednisolone pulse therapy for a life-threatening pulmonary insufficiency in a patient with chronic granulomatous disease following pulmonary invasive aspergillosis and Burkholderia cepacia infection.
MedLine Citation:
PMID:  10575344     Owner:  NLM     Status:  MEDLINE    
A 14-year-old boy with X-linked chronic granulomatous disease developed severe invasive pulmonary aspergillosis. He was treated with itraconazole and amphotericin B. However, he deteriorated with progressive pulmonary lesions. Burkholderia cepacia was isolated from his bronchoalveolar lavage. Finally, he was given granulocyte transfusions. Following this procedure, his condition rapidly worsened leading to respiratory failure. His lung biopsy demonstrated organizing pneumonia at his right middle lobe. Then, a methylprednisolone pulse therapy was initiated together with the administration of appropriate antibiotics and adequate amounts of amphotericin B. Dramatically, his condition improved. Therefore, a methylprednisolone pulse therapy with appropriate antimicrobial drugs seems to be beneficial for severe pulmonary insufficiency in this type of patients.
M Okano; M Yamada; M Ohtsu; N Kawamura; Y Sakiyama; K Aoi; S Gandoh; M Fujita; K Kobayashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  66     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-06-06     Completed Date:  2000-06-06     Revised Date:  2009-12-30    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  551-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 S. Karger AG, Basel
Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
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MeSH Terms
Antifungal Agents / administration & dosage
Aspergillosis / complications,  diagnosis,  drug therapy*
Burkholderia Infections / complications,  diagnosis,  drug therapy*
Burkholderia cepacia / isolation & purification*
Drug Therapy, Combination
Follow-Up Studies
Fungemia / complications,  diagnosis,  drug therapy*
Glucocorticoids / administration & dosage
Granulomatous Disease, Chronic / complications,  diagnosis
Lung Diseases, Fungal / complications,  diagnosis,  drug therapy*
Methylprednisolone / administration & dosage*
Pulmonary Valve Insufficiency / drug therapy*,  etiology
Pulse Therapy, Drug
Treatment Outcome
Reg. No./Substance:
0/Antifungal Agents; 0/Glucocorticoids; 83-43-2/Methylprednisolone

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