| Successful treatment with methylprednisolone pulse therapy for a life-threatening pulmonary insufficiency in a patient with chronic granulomatous disease following pulmonary invasive aspergillosis and Burkholderia cepacia infection. | |
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MedLine Citation:
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PMID: 10575344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 14-year-old boy with X-linked chronic granulomatous disease developed severe invasive pulmonary aspergillosis. He was treated with itraconazole and amphotericin B. However, he deteriorated with progressive pulmonary lesions. Burkholderia cepacia was isolated from his bronchoalveolar lavage. Finally, he was given granulocyte transfusions. Following this procedure, his condition rapidly worsened leading to respiratory failure. His lung biopsy demonstrated organizing pneumonia at his right middle lobe. Then, a methylprednisolone pulse therapy was initiated together with the administration of appropriate antibiotics and adequate amounts of amphotericin B. Dramatically, his condition improved. Therefore, a methylprednisolone pulse therapy with appropriate antimicrobial drugs seems to be beneficial for severe pulmonary insufficiency in this type of patients. |
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Authors:
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M Okano; M Yamada; M Ohtsu; N Kawamura; Y Sakiyama; K Aoi; S Gandoh; M Fujita; K Kobayashi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 66 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1999 Nov-Dec |
Date Detail:
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Created Date: 2000-06-06 Completed Date: 2000-06-06 Revised Date: 2009-12-30 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 551-4 Citation Subset: IM |
Copyright Information:
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Copyright 1999 S. Karger AG, Basel |
Affiliation:
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Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antifungal Agents / administration & dosage Aspergillosis / complications, diagnosis, drug therapy* Burkholderia Infections / complications, diagnosis, drug therapy* Burkholderia cepacia / isolation & purification* Drug Therapy, Combination Follow-Up Studies Fungemia / complications, diagnosis, drug therapy* Glucocorticoids / administration & dosage Granulomatous Disease, Chronic / complications, diagnosis Humans Lung Diseases, Fungal / complications, diagnosis, drug therapy* Male Methylprednisolone / administration & dosage* Pulmonary Valve Insufficiency / drug therapy*, etiology Pulse Therapy, Drug Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Glucocorticoids; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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