Document Detail


Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab.
MedLine Citation:
PMID:  15818709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positive experiences with intraarticular infliximab have been reported in patients with rheumatoid arthritis, ankylosing spondylitis, and Behcet's disease. We used intraarticular infliximab to treat resistant knee monarthritis in a patient with spondylarthropathy. Clinical and laboratory improvement was associated with improvement in scintigraphic findings. This approach is less expensive than intravenous administration of infliximab. We suggest that selection of candidates for this innovative therapy should be guided by anti-tumor necrosis factor alpha scintigraphy.
Authors:
Fabrizio Conti; Roberta Priori; Maria Sole Chimenti; Giulio Coari; Alessio Annovazzi; Guido Valesini; Alberto Signore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  52     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-6     Citation Subset:  AIM; IM    
Affiliation:
Università degli Studi di Roma La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / administration & dosage,  therapeutic use*
Antirheumatic Agents / administration & dosage,  therapeutic use*
Arthritis, Rheumatoid / complications,  diagnosis,  drug therapy*
Humans
Injections, Intra-Articular
Knee Joint / drug effects,  metabolism
Male
Radionuclide Imaging
Spondylitis, Ankylosing / complications,  diagnosis,  drug therapy*
Technetium / diagnostic use
Treatment Outcome
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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