Document Detail

Successful treatment with cyclosporine for myelodysplastic syndrome with erythroid hypoplasia following rheumatoid arthritis
MedLine Citation:
PMID:  20622490     Owner:  NLM     Status:  MEDLINE    
A 65-year-old female was admitted to our hospital for evaluation of transfusion-dependent progressive anemia. She had a history of rheumatoid arthritis for twenty-four years. Two years earlier, MDS (refractory anemia) was diagnosed based on laboratory findings and bone marrow examination. After diagnosis, the patient received anabolic steroid, Vitamin D3 and Vitamin K2. Although her hemoglobin level was maintained at 8.0 g/dl approximately 9.0 g/dl until January 2009, anemia gradually progressed thereafter. In April, we recognized marked anemia (Hb 6.0 g/dl) and reticulocytopenia (2.0 per thousand), but this was not accompanied by any other significant changes in laboratory findings. Bone marrow examination demonstrated a low percentage of erythroid precursors without an increase of blast cells. Rheumatoid arthritis remained stable by low dose steroid and NSAID administration. We did not recognize evidence suggesting any other cause of acquired PRCA, such as thymoma, human parvovirus B19 infection or drugs. A diagnosis of MDS with erythroid hypoplasia was made. The patient was successfully treated by an immunosuppressive regimen using cyclosporine. MDS with erythroid hypoplasia, coexisting with rheumatoid arthritis, is rare. To our knowledge, this is the third reported case.
Takahiro Tsuji; Hiroshi Yamasaki; Hiroyuki Tsuda
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article; Review    
Journal Detail:
Title:  [Rinshō ketsueki] The Japanese journal of clinical hematology     Volume:  51     ISSN:  0485-1439     ISO Abbreviation:  Rinsho Ketsueki     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984782R     Medline TA:  Rinsho Ketsueki     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  427-32     Citation Subset:  IM    
Division of Hematology and Oncology, Kumamoto City Hospital.
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MeSH Terms
Arthritis, Rheumatoid / complications*,  drug therapy
Cyclosporine / administration & dosage*
Erythroid Cells / pathology*
Immunosuppressive Agents / administration & dosage*
Myelodysplastic Syndromes / complications*,  diagnosis,  drug therapy*,  pathology
Treatment Outcome
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

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