Document Detail


Successful treatment of ventricular assist device associated ventricular thrombus with systemic tenecteplase.
MedLine Citation:
PMID:  17581787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of intracardiac thrombus in a patient supported by the Jarvik 2000 Flowmaker successfully treated with a single dose of peripherally administered TNK-tissue plasminogen activator (Tenecteplase, Metalyse, Boehringer Ingelheim). This strategy may be considered in the case of life-threatening VAD associated thrombosis to avoid the need for intracardiac drug delivery or VAD replacement. We also discuss the apparent increased thrombotic risk in patients receiving a VAD for chemotherapy induced cardiomyopathy and the implications this may have for the choice of VAD.
Authors:
H Hayes; L Dembo; R Larbalestier; G O'Driscoll
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-06-19
Journal Detail:
Title:  Heart, lung & circulation     Volume:  17     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
Affiliation:
Advanced Heart Failure & Cardiac Transplant Service, Royal Perth Hospital, Perth, Western Australia, Australia. helen.hayes@health.wa.gov.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Fibrinolytic Agents / therapeutic use*
Heart Ventricles / pathology
Heart-Assist Devices / adverse effects*
Humans
Male
Thrombosis / drug therapy*,  etiology
Tissue Plasminogen Activator / therapeutic use*
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 0/tenecteplase; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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