Document Detail

Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn.
MedLine Citation:
PMID:  20634329     Owner:  NLM     Status:  MEDLINE    
Vancomycin-resistant Enterococcus faecium (VRE) infection is a rare event in paediatric patients and often occurs under immunosuppression or after surgical intervention. We report what we believe to be the first paediatric case of ventriculitis due to VRE (in a 2-month-old infant) to be successfully treated with combined intravenous (i.v.) and intraventricular chloramphenicol after failure of i.v. linezolid and intraventricular gentamicin.
Carolin Hartmann; Corinna Peter; Elvis Hermann; Benno Ure; Ludwig Sedlacek; Gesine Hansen; Bettina Bohnhorst
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-07-15
Journal Detail:
Title:  Journal of medical microbiology     Volume:  59     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1371-4     Citation Subset:  IM    
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
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MeSH Terms
Acetamides / administration & dosage
Anti-Bacterial Agents / administration & dosage*
Cerebral Ventricles / microbiology*,  pathology
Cerebrospinal Fluid / cytology,  microbiology
Chloramphenicol / administration & dosage*
Encephalitis / diagnosis*,  drug therapy
Enterococcus faecium / drug effects,  isolation & purification*
Gentamicins / administration & dosage
Gram-Positive Bacterial Infections / diagnosis*,  drug therapy
Head / radiography
Infant, Newborn
Infusions, Intravenous
Injections, Intraventricular
Lumbosacral Region / radiography
Magnetic Resonance Imaging
Oxazolidinones / administration & dosage
Pelvis / radiography
Treatment Outcome
Vancomycin Resistance*
Reg. No./Substance:
0/Acetamides; 0/Anti-Bacterial Agents; 0/Gentamicins; 0/Oxazolidinones; 165800-03-3/linezolid; 56-75-7/Chloramphenicol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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