| Successful treatment of ulcerative colitis associated with hypereosinophilic syndrome/chronic eosinophilic leukemia. | |
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MedLine Citation:
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PMID: 21841337 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized. |
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Authors:
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Nobuyasu Awano; Tomiko Ryu; Naoki Yoshimura; Masakazu Takazoe; Shigehiro Kitamura; Masanori Tanaka |
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Publication Detail:
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Type: Journal Article Date: 2011-08-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 50 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1741-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Social Insurance Chuo General Hospital, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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