Document Detail

Successful treatment of soft tissue calcifications in uremia.
MedLine Citation:
PMID:  16985488     Owner:  NLM     Status:  MEDLINE    
The appearance of soft tissue calcifications in patients with chronic renal failure has been recognised as one of the serious complications of uremia. An elevated serum calcium-phosphate product has almost invariably been detected, although the exact mechanisms of precipitation are still not fully understood. Among the factors responsible for triggering the precipitation process are: hyperphosphatemia, secondary hyperparathyroidism, hypercalcemia, treatment with vitamin D3, etc. Phosphate binders have been used to prevent, among other things, soft tissue calcifications, and parathyroidectomy has most frequently been applied as the therapy of choice, once precipitation of calcium salts has occurred. We present a case of soft tissue calcifications in the gluteal regions of a chronic haemodialysis female patient. The therapy we chose was a combination of biphosphonate and deferoxamine. The patient was treated for two months. The regression of the soft tissue calcifications was very significant, as registered both clinically and radiologically. The exact mechanism by which this reversal was achieved needs further investigation.
Aleksandar Sikole; Ljupco Stojkovski; Koco Cakalaroski; Nicola Stojcev; Vili Amitov; Momir Polenakovic
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences     Volume:  27     ISSN:  0351-3254     ISO Abbreviation:  Prilozi     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-20     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189513     Medline TA:  Prilozi     Country:  Macedonia    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Nephrology, Clinical Centre, Ss. Cyril and Methodius University, Skopje, R. Macedonia.
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MeSH Terms
Calcinosis / drug therapy*,  etiology
Deferoxamine / administration & dosage
Diphosphonates / administration & dosage
Drug Therapy, Combination
Kidney Failure, Chronic / complications,  therapy
Middle Aged
Muscular Diseases / drug therapy*,  etiology
Renal Dialysis
Uremia / complications*
Reg. No./Substance:
0/Diphosphonates; 70-51-9/Deferoxamine

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