Document Detail

Successful treatment of severe cytophagic histiocytic panniculitis with cyclosporine A.
MedLine Citation:
PMID:  8792512     Owner:  NLM     Status:  MEDLINE    
Cytophagic histiocytic panniculitis (CHP) can be a severe variant of Weber-Christian disease characterized by the histopathologic appearance of lobular panniculitis infiltrated by histiocytes containing blood cell fragments and by a clinical course with marked systemic features including multiorgan failure, hypertriglyceridemia, and coagulopathy, which may lead to death. Therapy of CHP includes standard treatment for panniculitis, such as antimalarials, plus immunosuppressives for more severe cases. The response to treatment, however, is unpredictable. In several recent reports, cyclosporine A has been successfully used to treat panniculitis. We report a patient and review the literature on CHP and the use of cyclosporine A as therapy. Published reports reveal that in instances of severe CHP when cyclosporine A was not given, 19 of 27 patients died (70% mortality). When severe CHP was treated with cyclosporine A, rapid remission was achieved in our patient and all five previously published cases (0% mortality). We believe cyclosporine A is the drug of choice in severe CHP and should be considered in all such patients.
B E Ostrov; B H Athreya; A H Eichenfield; D P Goldsmith
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  25     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-01-24     Completed Date:  1997-01-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-13     Citation Subset:  IM    
Milton S. Hershey Medical Center, Penn State University School of Medicine, Hershey 17033, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Bone Marrow / pathology
Cyclosporine / therapeutic use*
Fever / complications
Indomethacin / therapeutic use
Leukocyte Count
Panniculitis, Nodular Nonsuppurative / diagnosis,  drug therapy*,  pathology
Skin / pathology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 53-86-1/Indomethacin; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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