Document Detail

Successful treatment of patients with paraquat intoxication: three case reports and review of the literature.
MedLine Citation:
PMID:  22556181     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid.
METHODS: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g).
RESULTS: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exudation, and both lungs clear of auscultation.
CONCLUSIONS: The protective effect of the lungs may have been due to timely treatment at adequate doses.
Qin Zhang; Wei-zhen Wu; Yuan-qiang Lu; Jie-zan Wang; An-dong Shang; Feng Yao; Yan Chen
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  13     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-09-10     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  413-8     Citation Subset:  IM    
Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
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MeSH Terms
Combined Modality Therapy
Cyclophosphamide / therapeutic use*
Glucocorticoids / therapeutic use*
Herbicides / poisoning
Immunosuppressive Agents / therapeutic use
Lung Injury / chemically induced,  therapy
Multiple Organ Failure / chemically induced*,  therapy*
Paraquat / poisoning*
Renal Insufficiency / chemically induced,  therapy
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 0/Herbicides; 0/Immunosuppressive Agents; 4685-14-7/Paraquat; 50-18-0/Cyclophosphamide

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