Document Detail


Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b.
MedLine Citation:
PMID:  8605279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteoporosis is frequently seen in systemic mastocytosis. Although diphosphonate therapy has been shown to be transiently effective, therapy options for this form of osteopenia are very limited. We have treated three patients with systemic mastocytosis and osteopenia successfully with interferon alpha-2b. Two patients had urticaria pigmentosa and two severe back pain due to vertebral compression fractures. All patients received a daily interferon dose of 3 x 5 mio units/week s.c. for a period of 6 months. Therapy was well tolerated, and back pain resolved in both patients. A marked decrease of mast cell numbers in the bone marrow and a significant increase of bone mineralization and bone density was observed in all patients. Our data suggest that alpha interferon may be a new treatment option for osteopenia in systemic mastocytosis.
Authors:
R Weide; K Ehlenz; W Lorenz; E Walthers; M Klausmann; K H Pflüger
Related Documents :
12201869 - Combination therapy for children with chronic hepatitis b virus infection.
9651559 - Efficacy and safety of systemic recombinant interferon-alpha in behçet's disease.
8398949 - Early response to haloperidol treatment in chronic schizophrenia.
15156489 - Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after ...
9444929 - Results of the multicenter natural interferon-alpha treatment for chronic hepatitis c: ...
2110199 - Lack of suppression of ige production by recombinant interferon gamma: a controlled tri...
21049559 - Segmental gastrectomy with radical lymph node dissection for early gastric cancer.
3915889 - Rectal administration of tenoxicam for the treatment of rheumatoid arthritis and arthro...
2135599 - Early screw removal for correction of occlusal discrepancies following rigid internal f...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of hematology     Volume:  72     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-05-23     Completed Date:  1996-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  41-3     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Philipps University, Marburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Interferon-alpha / administration & dosage*
Male
Mastocytosis / complications,  therapy*
Osteoporosis / etiology,  therapy*
Chemical
Reg. No./Substance:
0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Risk of hepatitis C virus (HCV) transmission by anti-HCV-negative blood components in Austria and Ge...
Next Document:  Autoimmune hemolytic anemia in patients with de novo acute myelocytic leukemia.