Document Detail

Successful treatment of obstructive sleep apnea syndrome improves autonomic nervous system dysfunction.
MedLine Citation:
PMID:  15835389     Owner:  NLM     Status:  MEDLINE    
Autonomic nervous system (ANS) dysfunction may be implicated in the subsequent development of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS). To confirm the relation between OSAS and ANS dysfunction, we prospectively investigated ANS function in 7 patients with moderate or severe OSAS; 7 healthy age-matched volunteers were for control. We also studied ANS function before and after treatment in the patients with OSAS to evaluate the effect of OSAS treatment on ANS dysfunction. The body mass index of patients with OSAS was 32.2 (27.4-45) (median [range]) kg/m2. The patients were treated by nasal continuous positive airway pressure (n = 5) or uvulopalatopharyngoplasty (n = 2). The apnea/hypopnea index decreased markedly from 42.1 (30.6-77.2) events/hr of sleep before treatment to 2.3 (1.4-3.8) after treatment. To evaluate ANS function, the coefficient of variation of the RR interval (CV-RR) and corrected QT (QTc) interval on the electrocardiogram at rest and the heart rate (HR) responses to blood pressure (BP) changes during the Valsalva maneuver were studied. Baseline HR of OSAS patients was significantly higher than that of the control subjects (p < .05). The Valsalva ratio (VR), baroreflex sensitivity (BRS), and CV-RR values in patients with OSAS were significantly lower than those of the control subjects (all, p < .005). However, there were no significant differences in systolic and diastolic BP or QTc intervals. After treatment, VR, BRS, and CV-RR values increased significantly compared with those before treatment in patients with OSAS (all, p < .05). There were no significant differences in systolic and diastolic BP, HR, or QTc intervals measured before and after treatment. These results suggest that impaired ANS function is present in patients with OSAS and can be improved by successful treatment of OSAS.
Ryoji Ito; Hironobu Hamada; Akihito Yokoyama; Miki Oshima; Hitoshi Katayama; Hiroshi Ohnishi; Toru Kadowaki; Sanae Ishimaru; Kazunori Irifune; Jitsuo Higaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  27     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:    2005 Feb-Apr
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
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MeSH Terms
Autonomic Nervous System Diseases / complications,  physiopathology*
Blood Pressure / physiology
Continuous Positive Airway Pressure / methods*
Heart Rate / physiology
Middle Aged
Otorhinolaryngologic Surgical Procedures / methods*
Palate, Soft / surgery
Pharynx / surgery
Reconstructive Surgical Procedures
Severity of Illness Index
Sleep Apnea, Obstructive / complications,  physiopathology,  therapy*
Treatment Outcome
Uvula / surgery
Valsalva Maneuver / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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