| Successful treatment of massive pulmonary embolism in a pregnant woman, with low-dose, slow infusion of tissue plasminogen activator. | |
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MedLine Citation:
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PMID: 20215840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary embolism (PE) is an important cause of morbidity and mortality during pregnancy. A 21-year-old pregnant woman presented with chest pain and progressive shortness of breath at 35 weeks of gestation. Her respiratory rate was 26 breaths/min. Electrocardiography showed sinus tachycardia and nonspecific ST-T changes. Her plasma D-dimer level was elevated (1,325 ng/ml). Transthoracic echocardiography revealed enlargement of the right ventricle and a large, highly mobile thrombus in the right atrium moving during diastole into the right ventricle. Doppler ultrasonography of the lower extremities showed bilateral acute deep femoral vein thrombosis. Following the diagnosis of right heart thrombosis with massive PE, low-dose and prolonged infusion of tissue-type plasminogen activator (25 mg in three hours) was administered. Echocardiography performed six hours after thrombolysis showed a significant decrease in the right ventricular size and complete lysis of the thrombus in the right heart. Thrombosis risk panel studies showed factor V Leiden homozygote mutation. A live newborn was delivered by cesarean section at 37 weeks of gestation. No complications were seen during a 6-month follow-up. |
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Authors:
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Murat Biteker; Nil?fer Ek?i Duran; Mehmet Ozkan |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: T?rk Kardiyoloji Derne?i ar?ivi : T?rk Kardiyoloji Derne?inin yay?n organ?d?r Volume: 38 ISSN: 1016-5169 ISO Abbreviation: Turk Kardiyol Dern Ars Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426239 Medline TA: Turk Kardiyol Dern Ars Country: Turkey |
Other Details:
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Languages: eng Pagination: 32-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Kartal Ko?uyolu Heart and Research Hospital, Istanbul, Turkey. murbit2@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cesarean Section Echocardiography Female Femoral Vein / ultrasonography Heart Murmurs / ultrasonography Humans Infant, Newborn Pregnancy Pregnancy Complications / ultrasonography* Pulmonary Embolism / ultrasonography* Thrombolytic Therapy Tissue Plasminogen Activator / therapeutic use* Treatment Outcome Ultrasonography, Doppler Venous Thrombosis / ultrasonography Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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