| Successful treatment of a large hemangioma with propranolol. | |
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MedLine Citation:
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PMID: 19788583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemangiomas are the most common vascular tumors in children. They occur in 8-12% of all infants and in 22% of premature infants (female: male = 3: 1). Hemangiomas are usually sporadic; their etiology is unknown. A premature female infant, born at 28 weeks of gestation, presented with a large hemangioma of the right thoracic wall. Within the first few weeks, the hemangioma showed rapid horizontal and vertical growth as well as ulceration, which led us to initiate systemic therapy. The effectiveness of propranolol (non-selective ss-blocker) in the management of severe cases of hemangioma has been shown in a recent series of cases. We began oral propranolol treatment, in close interdisciplinary cooperation. After a few days of therapy, the tumor had stopped expanding. After 18 weeks, there has been marked regression but the therapy is still being continued. We propose that propranolol may be an effective and relatively well tolerable alternative in the management of selected cases of severe hemangiomas in infancy, providing interdisciplinary cooperation between dermatologists and pediatricians is available. |
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Authors:
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Waseem Mousa; Kirsten Kues; Ellen Haas; Peter Lauerer; Helena Pavlakovic; Michael P Schön; Markus Zutt |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-25 |
Journal Detail:
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Title: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG Volume: 8 ISSN: 1610-0387 ISO Abbreviation: J Dtsch Dermatol Ges Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101164708 Medline TA: J Dtsch Dermatol Ges Country: Germany |
Other Details:
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Languages: eng; ger Pagination: 184-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Venereology and Allergology, Georg August University Göttingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hemangioma / drug therapy* Humans Infant, Newborn Infant, Premature Propranolol / administration & dosage* Thoracic Neoplasms / drug therapy* Treatment Outcome Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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