Document Detail


Successful treatment of a large hemangioma with propranolol.
MedLine Citation:
PMID:  19788583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemangiomas are the most common vascular tumors in children. They occur in 8-12% of all infants and in 22% of premature infants (female: male = 3: 1). Hemangiomas are usually sporadic; their etiology is unknown. A premature female infant, born at 28 weeks of gestation, presented with a large hemangioma of the right thoracic wall. Within the first few weeks, the hemangioma showed rapid horizontal and vertical growth as well as ulceration, which led us to initiate systemic therapy. The effectiveness of propranolol (non-selective ss-blocker) in the management of severe cases of hemangioma has been shown in a recent series of cases. We began oral propranolol treatment, in close interdisciplinary cooperation. After a few days of therapy, the tumor had stopped expanding. After 18 weeks, there has been marked regression but the therapy is still being continued. We propose that propranolol may be an effective and relatively well tolerable alternative in the management of selected cases of severe hemangiomas in infancy, providing interdisciplinary cooperation between dermatologists and pediatricians is available.
Authors:
Waseem Mousa; Kirsten Kues; Ellen Haas; Peter Lauerer; Helena Pavlakovic; Michael P Schön; Markus Zutt
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-09-25
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  8     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng; ger     Pagination:  184-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Venereology and Allergology, Georg August University Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Female
Hemangioma / drug therapy*
Humans
Infant, Newborn
Infant, Premature
Propranolol / administration & dosage*
Thoracic Neoplasms / drug therapy*
Treatment Outcome
Vasodilator Agents / administration & dosage
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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