Document Detail

Successful treatment of kasabach-merritt phenomenon with intralesional corticosteroid injections: a case series.
MedLine Citation:
PMID:  23154333     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: Kasabach-Merritt phenomenon (KMP) is a rare and life-threatening disease of vascular tumor combined with severe consumptive coagulopathy. Currently, there is no established effective treatment of KMP. In this case series, from 2006 to 2008, we treated 6 pediatric patients with newly diagnosed KMP using intralesional corticosteroid injections. The severity and progression of the disease were closely monitored with clinical photographs, blood sampling, and tissue biopsies. The 6 pediatric patients (5 females and 1 male) showed tumor regression after treatments. All coagulopathies were corrected. The average duration of treatment was 3.8 months. Complete tumor regression was observed at approximately 3 years. Treatment was complicated in 1 patient with transient growth retardation. Treatment based on intralesional corticosteroid injections is effective for pediatric patients with KMP. Treatment-associated complications seemed to be reversible and acceptable by severity level.
Jian-Jr Lee; Li-Ying Lin; Shun-Wen Hsieh; Ting-An Chang; Shiann-Tarng Jou; Charlos Chih-Ho Liu; Ming-Ting Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  69     ISSN:  1536-3708     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-32     Citation Subset:  IM    
From the *Division of Plastic Surgery, Department of Surgery, Cathay General Hospital; †Department of Pathology, Taipei Hospital, Department of Health; ‡Department of Pathology, Renai Branch of Taipei City Hospital; §Department of Pediatrics, National Taiwan University Hospital; ||Department of Computer Science and Information Engineering, National Taiwan University; and ¶Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
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