Document Detail


Successful treatment of intractable gastric ulcers with acetazolamide.
MedLine Citation:
PMID:  2130365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An open-controlled trial performed in gastric ulcer cases resistant to previous cimetidine, antacids, vitamin A and polyvinylbutylether therapy applied for at least 4 weeks. A group of 21 patients treated with acetazolamide was compared with 16 patients treated with cimetidine (controls). The period of management was 3 weeks. The number of healed patients (P = 0.009), the surfaces of ulcers after treatment (P = 0.0166) and the duration of complaints (P = 0.0003) differed favourably and significantly in the acetazolamide group as compared to the cimetidine group. In the acetazolamide group, however, several side effects (in 11 cases metabolic acidosis, in 9 cases tingling of extremities) were registered. Side effects were not seen in the control group. It is supposed that in the treatment of gastric ulcers a compound with less carbonic anhydrase inhibition but with the same or more cytoprotective effect would have wider clinical perspectives than acetazolamide alone.
Authors:
A Erdei; I Gyóri; A Gedeon; I Szabó
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta medica Hungarica     Volume:  47     ISSN:  0236-5286     ISO Abbreviation:  Acta Med Hung     Publication Date:  1990  
Date Detail:
Created Date:  1991-11-08     Completed Date:  1991-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400269     Medline TA:  Acta Med Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  171-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Central Laboratory Bugát Pál Hospital, Gyöngyös, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / adverse effects,  therapeutic use*
Cimetidine / adverse effects,  therapeutic use
Humans
Pain
Prospective Studies
Stomach Ulcer / drug therapy*,  pathology,  physiopathology
Chemical
Reg. No./Substance:
51481-61-9/Cimetidine; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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