Document Detail

Successful treatment of four patients with recalcitrant vaginal trichomoniasis with a combination of zinc sulfate douche and metronidazole therapy.
MedLine Citation:
PMID:  9111758     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: There is no certain cure available for patients suffering from recalcitrant trichomoniasis. Zinc sulfate is reported to have antitrichomonal properties. We report our experience in treating four patients empirically with a combination of zinc sulfate douche and metronidazole. STUDY DESIGN: A retrospective case analysis. Patients who presented to the tertiary referral clinic with chronic recurrent trichomoniasis without evidence of reinfection were treated empirically with a combination of zinc sulfate douching (1%) followed by a metronidazole 500 mg suppository per vaginale twice daily and 200 to 400 mg three times a day orally. The douching and suppository were used prophylactically for 3 nights after menstruation for some months. RESULTS: Four patients who had a history of 4 months to 4 years of culture-positive symptomatic trichomoniasis and received a variety of therapies before referral were treated successfully. At the review of 2 to 5 months after therapy, all had remained asymptomatic and the results of clinical and laboratory examinations were normal. CONCLUSIONS: The exact role of zinc sulfate douching in the successful outcome is not certain, but the combination therapy requires only a moderate dose of metronidazole (1.6-2.2 g/day), avoiding the side effects of larger doses. The combination therapy therefore merits further evaluation.
E T Houang; Z Ahmet; A G Lawrence
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  24     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-9     Citation Subset:  IM    
Department of Microbiology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
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MeSH Terms
Drug Therapy, Combination
Metronidazole / administration & dosage*
Retrospective Studies
Trichomonas Vaginitis / drug therapy*
Zinc Sulfate / administration & dosage*
Reg. No./Substance:
443-48-1/Metronidazole; 7733-02-0/Zinc Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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