Document Detail

Successful treatment of fetal intraperitoneal administration of immunoglobulin in a case of fetal hemolytic anemia with 131,072-fold anti-e alloimmunization.
MedLine Citation:
PMID:  22567491     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Object. We present here the case of severe fetal anemia caused by anti-E antibody positive, which showed a favorable course only with fetal intraperitoneal administration of immunoglobulin. Case. The mother was 31 years old, blood type B Rh : CCDee, gravida 1, with no history of transfusion. Anti-E antibody was detected in the maternal cross-match test at the 18th gestational week. In percutaneous umbilical blood sampling, the umbilical blood hemoglobin level was 9.1 g/dL and the result of the direct Coombs' test was positive at the 26th gestational week. Immunoglobulin injection into fetal abdominal cavity (IFAC) was administered a total 7 times. During the pregnancy, the indirect Coombs' test showed a 131,072-fold increase. Conclusion. In this case, IFAC to block the reticuloendothelial system Fc receptor was successful. This procedure is promising as one of the treatment options for blood group incompatible pregnancy.
Masashi Yoshida; Hideo Matsuda; Eijiro Hayata; Akio Watanabe; Miho Oeda; Kenichi Furuya
Publication Detail:
Type:  Journal Article     Date:  2011-11-17
Journal Detail:
Title:  Case reports in obstetrics and gynecology     Volume:  2011     ISSN:  2090-6692     ISO Abbreviation:  Case Rep Obstet Gynecol     Publication Date:  2011  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101576454     Medline TA:  Case Rep Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157510     Citation Subset:  -    
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