Document Detail

Successful treatment of familial Mediterranean fever attacks with thalidomide in a colchicine resistant patient.
MedLine Citation:
PMID:  12371635     Owner:  NLM     Status:  MEDLINE    
Colchicine is the treatment of choice in familial Mediterranean fever (FMF) both for attacks and for prevention of secondary amyloidosis. The overall non-responder rate varies from 5-10 to 40%. Thalidomide is known to blunt the acute phase response. We report the efficacy of the addition of thalidomide to colchicine in controlling the febrile attacks and acute phase response in a patient with FMF resistant to 2 mg colchicine per day.
E Seyahi; H Ozdogan; S Masatlioglu; H Yazici
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  20     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-10-09     Completed Date:  2003-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S43-4     Citation Subset:  IM    
Department of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
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MeSH Terms
Colchicine / therapeutic use*
Drug Therapy, Combination
Familial Mediterranean Fever / drug therapy*
Immunosuppressive Agents / therapeutic use*
Middle Aged
Thalidomide / therapeutic use*
Reg. No./Substance:
0/Immunosuppressive Agents; 50-35-1/Thalidomide; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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