Document Detail

Successful treatment of extremely severe fetal anemia due to anti-Jra alloimmunization.
MedLine Citation:
PMID:  16601336     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although Jr(a) hemolytic disease of the newborn (HDN) is generally considered to be mild, we encountered a case of anti-Jr(a) alloimmunization hydrops fetalis due to extremely severe fetal anemia that required aggressive intrauterine treatment. CASE REPORT: A Japanese woman developed hydrops fetalis at the 29th week of gestation. Blood examination was highly positive for anti-Jr(a) antibodies. Cordocentesis demonstrated that the fetus had anti-Jr(a) antibodies and the lowest fetal hemoglobin concentration was 2.3 g/dl. After a total of four intravascular transfusions, fetal hydrops improved and a healthy girl of 2,120 g was delivered at the 35th week of gestation. The initial neonatal hemoglobin concentration at birth was 7.2 g/dl. After two straight transfusions, the infant's anemia did not worsen. Anti-Jr(a) antibodies became negative without developing hyperbilirubinemia. CONCLUSION: The incidence of Jr(a) negativity can lead to underestimation of the risk of Jr(a) alloimmunization. This case shows that anti-Jr(a) alloimmunization may cause HDN and hydrops fetalis.
Yuki Ishihara; Shigeki Miyata; Yoshihide Chiba; Takeshi Kawai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  21     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  269-71     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Perinatology, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Anemia / immunology,  therapy*
Blood Group Antigens / immunology*
Blood Group Incompatibility / complications*
Blood Transfusion, Intrauterine*
Fetal Blood / chemistry
Fetal Diseases / immunology,  therapy*
Gestational Age
Hemoglobins / analysis
Hydrops Fetalis / immunology,  therapy
Isoantibodies / blood
Pregnancy Outcome
Reg. No./Substance:
0/Blood Group Antigens; 0/Hemoglobins; 0/Isoantibodies

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