| Successful treatment of a complicated case of neuroleptic malignant syndrome. | |
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MedLine Citation:
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PMID: 12122539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists. |
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Authors:
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A Lappa; M Podestà; O Capelli; A Castagna; G Di Placido; D Alampi; F Semeraro |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2002-06-07 |
Journal Detail:
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Title: Intensive care medicine Volume: 28 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-17 Completed Date: 2002-11-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 976-7 Citation Subset: IM |
Affiliation:
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Intensive Care Unit, M.G. Vannini Hospital, Via A. Bullicante no. 4, 00177 Rome, Italy. aldo.castagna@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Antipsychotic Agents / adverse effects Dantrolene / therapeutic use Disseminated Intravascular Coagulation / complications Female Fluid Therapy Humans Infusions, Intravenous Italy Monoamine Oxidase Inhibitors / administration & dosage, adverse effects Muscle Relaxants, Central / therapeutic use Neuroleptic Malignant Syndrome / complications, drug therapy* Rhabdomyolysis / complications Tranylcypromine / administration & dosage, adverse effects Treatment Outcome* Trifluoperazine / administration & dosage, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Monoamine Oxidase Inhibitors; 0/Muscle Relaxants, Central; 117-89-5/Trifluoperazine; 155-09-9/Tranylcypromine; 7261-97-4/Dantrolene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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