Document Detail

Successful treatment of a complicated case of neuroleptic malignant syndrome.
MedLine Citation:
PMID:  12122539     Owner:  NLM     Status:  MEDLINE    
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists.
A Lappa; M Podestà; O Capelli; A Castagna; G Di Placido; D Alampi; F Semeraro
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2002-06-07
Journal Detail:
Title:  Intensive care medicine     Volume:  28     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  976-7     Citation Subset:  IM    
Intensive Care Unit, M.G. Vannini Hospital, Via A. Bullicante no. 4, 00177 Rome, Italy.
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MeSH Terms
Administration, Oral
Antipsychotic Agents / adverse effects
Dantrolene / therapeutic use
Disseminated Intravascular Coagulation / complications
Fluid Therapy
Infusions, Intravenous
Monoamine Oxidase Inhibitors / administration & dosage,  adverse effects
Muscle Relaxants, Central / therapeutic use
Neuroleptic Malignant Syndrome / complications,  drug therapy*
Rhabdomyolysis / complications
Tranylcypromine / administration & dosage,  adverse effects
Treatment Outcome*
Trifluoperazine / administration & dosage,  adverse effects
Reg. No./Substance:
0/Antipsychotic Agents; 0/Monoamine Oxidase Inhibitors; 0/Muscle Relaxants, Central; 117-89-5/Trifluoperazine; 155-09-9/Tranylcypromine; 7261-97-4/Dantrolene

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