Document Detail

Successful treatment of coccidioidomycosis osteomyelitis in an infant.
MedLine Citation:
PMID:  8342934     Owner:  NLM     Status:  MEDLINE    
A 10-month-old Hispanic male infant with expansile lesions of the third metacarpal and proximal phalanx positively diagnosed as Coccidioides immitis osteomyelitis is presented. Treatment consisted of combined surgical debridement and systemic antifungal therapy and resulted in complete resolution of the lesions. Treatment was guided by clinical response and complement fixation titers. Osteomyelitis is a relatively infrequent manifestation of disseminated coccidioidomycosis. Neonates and infants appear to be more susceptible to the development of dissemination, but less likely to develop toxicity due to systemic therapy. Current therapy consists of concomitant surgical excision of involved lesions and systemic antifungal therapy. Complement fixation titers correlate closely with clinical response to therapy and are useful in detecting subclinical recurrences.
K D Bickel; B H Press; L M Hovey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  30     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Department of Plastic and Reconstructive Surgery, Stanford University School of Medicine, CA.
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MeSH Terms
Amphotericin B / therapeutic use
Coccidioidomycosis / therapy*
Combined Modality Therapy
Osteomyelitis / microbiology*,  therapy
Reg. No./Substance:
1397-89-3/Amphotericin B

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