Document Detail

Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases
MedLine Citation:
PMID:  20068277     Owner:  NLM     Status:  MEDLINE    
We report here two patients with chronic disseminated intravascular coagulation (chronic DIC) secondary to aortic aneurysm, who were successfully treated with continuous subcutaneous infusion of heparin. The patients were 69- and 89-year-old males, who were admitted to our hospital because of thrombocytopenia and marked bleeding tendency. The underlying conditions were aortic dissection and aortic aneurysm, respectively. Coagulation test demonstrated that these patients had DIC, and a diagnosis of chronic DIC secondary to aortic aneurysm was made. Anti-coagulation treatment with oral camostat mesylate and daily subcutaneous infusion of heparin calcium was started. However, the treatment was insufficient to control chronic DIC, and these patients developed recurrent severe subcutaneous hemorrhages. Therefore, we attempted continuous subcutaneous infusion of heparin using a mobile infusion pump. This delivery of heparin markedly improved the coagulopathy, and the hemorrhagic episode disappeared with good compliance in the use of infusion equipment in these patients. Continuous subcutaneous infusion of heparin using a mobile infusion pump is effective and useful for long term treatment of chronic DIC by the outpatient department.
Katsuhiro Togami; Yuya Nagai; Hiroshi Arima; Sonoko Shimoji; Takahiro Kimura; Daichi Inoue; Minako Mori; Haruyuki Fujita; Sumie Tabata; Masayuki Kurata; Soshi Yanagida; Akiko Matsushita; Kenichi Nagai; Shuichiroh Kaji; Takayuki Takahashi
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Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  [Rinsh? ketsueki] The Japanese journal of clinical hematology     Volume:  50     ISSN:  0485-1439     ISO Abbreviation:  Rinsho Ketsueki     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984782R     Medline TA:  Rinsho Ketsueki     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1700-5     Citation Subset:  IM    
Department of Hematology, Kobe City Medical Center, General Hospital.
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MeSH Terms
Aged, 80 and over
Aneurysm, Dissecting / complications
Anticoagulants / administration & dosage*
Aortic Aneurysm / complications
Chronic Disease
Disseminated Intravascular Coagulation / drug therapy*,  etiology
Heparin / administration & dosage*
Infusion Pumps
Infusions, Subcutaneous
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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