Document Detail

Successful treatment of central nervous system juvenile xanthogranulomatosis with cladribine.
MedLine Citation:
PMID:  18989881     Owner:  NLM     Status:  MEDLINE    
Juvenile xanthogranulomatosis (JXG) is an uncommon histiocytic disease that is usually limited to the skin. Here we describe an infant with systemic JXG including a central nervous system (CNS) lesion. He was initially treated with prednisolone and vinblastine but developed an idiosyncratic reaction to prednisolone that was discontinued. The lesion then failed to respond to vinblastine monotherapy. Treatment with cladribine (2-chlorodeoxyadenosine) was subsequently successful with radiological resolution of the CNS lesion.
Barathi Rajendra; Alison Duncan; Richard Parslew; Barry L Pizer
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  52     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-5     Citation Subset:  IM    
Department of Oncology, RLC NHS Trust, Alder Hey, Liverpool, UK.
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MeSH Terms
Central Nervous System Diseases / drug therapy*,  radiography
Cladribine / therapeutic use*
Follow-Up Studies
Tomography, X-Ray Computed
Xanthogranuloma, Juvenile / drug therapy*,  radiography
Reg. No./Substance:

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