| Successful treatment by defibrination with ancrod in a patient with hyperacute renal allograft failure and a deficiency of plasma prostacyclin stimulating factor. | |
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MedLine Citation:
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PMID: 6754189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperacute and renal allograft failure, whether due to rejection or other mechanisms, such as perfusion injury, is usually associated with extensive intraglomerular fibrin deposition and allograft loss. Defibrination with ancrod was used to treat a patient with hyperacute renal allograft failure and extensive glomerular fibrin deposition and necrosis. The patient's plasma had normal fibrinolytic activity but a complete absence of the ability to generate prostacyclin-like activity from rat aortic endothelium "in vitro". Treatment was associated with complete recovery of renal function, disappearance of glomerular fibrin, and restoration toward normal of glomerular structure. |
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Authors:
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A K Dosekun; M R First; P K Chandran; K S Kant; P Glas-Greenwalt; M A Weiss; J W Alexander; V E Pollak |
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Publication Detail:
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Type: Case Reports; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical nephrology Volume: 18 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ancrod / pharmacology, therapeutic use* Biological Products / analysis, deficiency* Biopsy Epoprostenol / blood, deficiency* Female Fibrin / analysis Graft Rejection / drug effects* Humans Kidney / pathology Kidney Diseases / blood, drug therapy*, pathology Kidney Glomerulus / analysis, pathology Kidney Transplantation* Prostaglandins / deficiency* |
| Grant Support | |
ID/Acronym/Agency:
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AM 20711/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Prostaglandins; 35121-78-9/Epoprostenol; 9001-31-4/Fibrin; EC 3.4.21.-/Ancrod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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