Document Detail

Successful treatment by defibrination with ancrod in a patient with hyperacute renal allograft failure and a deficiency of plasma prostacyclin stimulating factor.
MedLine Citation:
PMID:  6754189     Owner:  NLM     Status:  MEDLINE    
Hyperacute and renal allograft failure, whether due to rejection or other mechanisms, such as perfusion injury, is usually associated with extensive intraglomerular fibrin deposition and allograft loss. Defibrination with ancrod was used to treat a patient with hyperacute renal allograft failure and extensive glomerular fibrin deposition and necrosis. The patient's plasma had normal fibrinolytic activity but a complete absence of the ability to generate prostacyclin-like activity from rat aortic endothelium "in vitro". Treatment was associated with complete recovery of renal function, disappearance of glomerular fibrin, and restoration toward normal of glomerular structure.
A K Dosekun; M R First; P K Chandran; K S Kant; P Glas-Greenwalt; M A Weiss; J W Alexander; V E Pollak
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Publication Detail:
Type:  Case Reports; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical nephrology     Volume:  18     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
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MeSH Terms
Ancrod / pharmacology,  therapeutic use*
Biological Products / analysis,  deficiency*
Epoprostenol / blood,  deficiency*
Fibrin / analysis
Graft Rejection / drug effects*
Kidney / pathology
Kidney Diseases / blood,  drug therapy*,  pathology
Kidney Glomerulus / analysis,  pathology
Kidney Transplantation*
Prostaglandins / deficiency*
Grant Support
Reg. No./Substance:
0/Biological Products; 0/Prostaglandins; 35121-78-9/Epoprostenol; 9001-31-4/Fibrin; EC 3.4.21.-/Ancrod

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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