| Successful treatment of basal cell carcinomas in a nevoid basal cell carcinoma syndrome with topical 5% imiquimod. | |
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MedLine Citation:
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PMID: 12459530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gorlin-Goltz syndrome, also referred to as naevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant skin disease with complete penetrance and inconstancy of the four major findings: multiple naevoid basal cell carcinomas (BCCs), pits on palms and soles, skeletal abnormalities (for example, jaw cysts), and ectopic calcification. The treatment of multiple BCCs is still a matter of debate. We report three cases of multiple BCCs in Gorlin-Goltz syndrome treated with topical 5% imiquimod cream, an immune response modifier. Patients were successfully cleared of BCCs after treatment for 6-8 weeks. Histologically no apparent signs of BCC-persistence could be detected and no recurrences were detected during the 12 month follow up period. |
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Authors:
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Eggert Stockfleth; Claas Ulrich; Axel Hauschild; Stephan Lischner; Thomas Meyer; Enno Christophers |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: 12 ISSN: 1167-1122 ISO Abbreviation: Eur J Dermatol Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-12-02 Completed Date: 2003-03-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: France |
Other Details:
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Languages: eng Pagination: 569-72 Citation Subset: IM |
Affiliation:
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Department of Dermatology of the Charité, Humboldt University, Schumannstra e 20/21, 10117 Berlin, Germany. E.Stockfleth@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Aminoquinolines / administration & dosage* Basal Cell Nevus Syndrome / drug therapy*, pathology Biopsy, Needle Dose-Response Relationship, Drug Drug Administration Schedule Face Female Follow-Up Studies Humans Immunohistochemistry Male Middle Aged Sampling Studies Skin Neoplasms / drug therapy*, pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Aminoquinolines; 99011-02-6/imiquimod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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