| Successful treatment of acute promyelocytic leukaemia during pregnancy. | |
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MedLine Citation:
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PMID: 12358893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case is reported of a pregnant 16-year-old-woman diagnosed with Acute promyelocytic leukaemia (APL) at 25 weeks gestation and treated with all-trans retinoic acid (ATRA) (45 mg/m2) for 25 days in combination with chemotherapy. She achieved a complete cytogenetic and molecular remission. Clinical course was complicated, with an intracerebral bleed, respiratory failure requiring ventilation and prolonged pancytopenia following initial chemotherapy. A live female infant was born at 28 weeks gestation who survived to discharge with significant pulmonary complications. She remains oxygen dependent at 6 months of age. ATRA has been used from the 3rd week of gestation, but fetal malformations are common during the first trimester. In contrast it seems to be safe in the second and third trimesters with regard to teratogenesis but can cause other side-effects. Most successful outcomes in treatment of APL during pregnancy are seen after treatment with ATRA and delivery of the baby at as late a stage as possible. Pregnancies terminated before remission has been obtained or those treated in the first trimester have a poor maternal outcome. |
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Authors:
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D Carradice; N Austin; K Bayston; P S Ganly |
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22169833 - Pathogens and the placental fortress. 22078463 - Access to safe abortion: building choices for women living with hiv and aids. 22169833 - Pathogens and the placental fortress. |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and laboratory haematology Volume: 24 ISSN: 0141-9854 ISO Abbreviation: Clin Lab Haematol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-02 Completed Date: 2003-03-17 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7907061 Medline TA: Clin Lab Haematol Country: England |
Other Details:
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Languages: eng Pagination: 307-11 Citation Subset: IM |
Affiliation:
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Department of Haematology, Christchurch Hospital, New Zealand. duncancarradice@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticonvulsants / therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Cerebral Hemorrhage / drug therapy, etiology Cesarean Section Dexamethasone / therapeutic use Diuretics / therapeutic use Epilepsy, Tonic-Clonic / drug therapy, etiology Female Fetal Growth Retardation / etiology Humans Idarubicin / administration & dosage Infant, Newborn Leukemia, Promyelocytic, Acute / complications, drug therapy* Lung / abnormalities Neutropenia / chemically induced Nutrition Disorders / etiology, therapy Oxygen / therapeutic use Parenteral Nutrition, Total Pregnancy Pregnancy Complications / etiology, therapy Pregnancy Complications, Neoplastic / drug therapy* Remission Induction Respiration Disorders / congenital, etiology Tranexamic Acid / therapeutic use Tretinoin / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Diuretics; 1197-18-8/Tranexamic Acid; 302-79-4/Tretinoin; 50-02-2/Dexamethasone; 58957-92-9/Idarubicin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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