Document Detail


Successful treatment of acquired amegakaryocytic thrombocytopenic purpura refractory to corticosteroids and intravenous immunoglobulin with antithymocyte globulin and cyclosporin.
MedLine Citation:
PMID:  18626728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four patients with acquired amegakaryocytic thrombocytopenic purpura, who had failed corticosteroids, intravenous immunoglobulin and cyclophosphamide therapy, were treated with antithymocyte globulin, followed by cyclosporin. Three patients achieved complete remission in 28-178 days and the response duration was 16-60 months from the beginning of treatment. One patient achieved a partial response for 2 months followed by myelodysplastic syndrome 5 months later. He died in 9 months due to intracerebral bleeding. Marrow cytogenetics showed 47, XY, +21.
Authors:
Pimjai Niparuck; Vichai Atichartakarn; Suporn Chuncharunee
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-07-15
Journal Detail:
Title:  International journal of hematology     Volume:  88     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Affiliation:
Department of Hematology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. pimjai1976@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Aged
Antilymphocyte Serum / administration & dosage*
Cyclosporine / administration & dosage*
Drug Resistance
Female
Humans
Immunoglobulins, Intravenous / therapeutic use
Immunosuppressive Agents / administration & dosage*
Male
Megakaryocytes / pathology
Middle Aged
Purpura, Thrombocytopenic / drug therapy*,  immunology,  pathology
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antilymphocyte Serum; 0/Immunoglobulins, Intravenous; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

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