Document Detail


Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1.
MedLine Citation:
PMID:  22170537     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aciclovir (ACV)-resistant Herpes simplex virus type-2 (HSV-2) infections are observed commonly in patients also infected with HIV-1. The use of foscarnet (FOS) in these patients may also lead to resistance. This situation can become a difficult therapeutic challenge. Four cases of patients infected with HIV and with mucocutaneous HSV-2 resistant to ACV and FOS are reported. These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions. J. Med. Virol. 84:194-197, 2012. © 2011 Wiley Periodicals, Inc.
Authors:
Anne-Sophie Lascaux; Eric Caumes; Claire Deback; Giovanna Melica; Dominique Challine; Henri Agut; Yves Lévy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  84     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2011-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Clinical Immunology, Hôpital Henri Mondor, Créteil, France. anne-sophie.lascaux@hmn.aphp.fr.
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