| Successful treatment of Kasabach-Merritt syndrome with prednisone and epsilon-aminocaproic acid. | |
| | |
MedLine Citation:
|
PMID: 1669958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Kasabach-Merritt syndrome is characterized by thrombocytopenia and localized coagulopathy associated with a hemangioma. Most techniques applied to eradicate the tumor or accelerate its involution (surgery, radiation therapy, embolization) are invasive and require transfusion of large amounts of blood products. In some cases, medical treatment is the only alternative. Efficacy of steroids and antifibronolytic agents has already been described, but even this approach is associated with the administration of blood products. We report two cases of infants with Kasabach-Merritt syndrome associated with cardiac and hepatic hemangiomas. At admission, both had signs of cardiac failure. They were successfully treated with prednisone and epsilon-aminocaproic acid (EACA). Blood products were not required once the diagnosis was made. These observations have important implications for the management of patients with Kasabach-Merritt syndrome because they show that even in severe cases blood transfusions can be avoided by the use of prednisone and EACA. |
| | |
Authors:
|
M F Dresse; M David; H Hume; H Blanchard; P Russo; N Van Doesberg; G E Rivard |
Related Documents
:
|
3780268 - Intracranial gyriform calcification associated with subarachnoid fat. 11051628 - Case report: one-and-a-half-syndrome and tuberculosis of the pons in a patient with aids. 7724128 - Kasabach-merritt coagulopathy complicating klippel-trenaunay-weber syndrome in pregnancy. 15519118 - Leptomeningeal angiomatosis with infantile spasms. 8161228 - Congener-specific data on polychlorinated biphenyls in tissues of common porpoise from ... 17431898 - Ovotestes and xy sex reversal in a female with an interstitial 9q33.3-q34.1 deletion en... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric hematology and oncology Volume: 8 ISSN: 0888-0018 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 1991 Oct-Dec |
Date Detail:
|
Created Date: 1992-03-18 Completed Date: 1992-03-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 329-34 Citation Subset: IM |
Affiliation:
|
Hematology-Oncology, Hôpital Sainte-Justine, Montreal, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
6-Aminocaproic Acid
/
therapeutic use* Disseminated Intravascular Coagulation / drug therapy* Drug Therapy, Combination Female Heart Failure / drug therapy Heart Neoplasms / drug therapy Hemangioma / drug therapy* Humans Infant Infant, Newborn Liver Neoplasms / drug therapy Male Prednisone / therapeutic use* Syndrome Thrombocytopenia / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
53-03-2/Prednisone; 60-32-2/6-Aminocaproic Acid |
| Comments/Corrections | |
Comment In:
|
Pediatr Hematol Oncol. 1993 Apr-Jun;10(2):197-8
[PMID:
8318377
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulmonary toxicity of gold salts
Next Document: Microbiological agents as health risks in indoor air.