Document Detail

Successful treatment of Candida albicans septicemia in a preterm infant with severe congenital ichthyosis (Harlequin baby).
MedLine Citation:
PMID:  19840314     Owner:  NLM     Status:  MEDLINE    
Candida infections are a major cause of fungal septicemia in neonates and are associated with marked morbidity and mortality. Despite the spectrum of antifungal drugs being dramatically extended during the last decade, invasive fungal infections remain a serious challenge for neonatologists. Amphotericin B and its lipid formulations are the drugs of choice for the treatment of systemic candidiasis in neonates. The combination of antifungal drugs with different sites of action, like caspofungin and amphotericin B, may improve antifungal efficacy. Severe congenital ichthyosis often leads to death within the neonatal period. Main causes of death are dehydration, electrolyte disturbances, and respiratory or systemic infections. We report the case of a preterm infant with severe congenital ichthyosis and sepsis caused by Candida albicans. The infection did not improve despite proper liposomal amphotericin B treatment. After addition of caspofungin, the baby recovered. To our best knowledge, a case of a preterm infant suffering from severe congenital ichthyosis and Candida albicans sepsis, who survived, has not been previously described.
Roland Haase; Burkhard Kreft; J??rgen Foell; Alexander S Kekul??; Nick Merkel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  26     ISSN:  1525-1470     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-8     Citation Subset:  IM    
Department of neonatology, Clinic for Child and Adolescent Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany.
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MeSH Terms
Amphotericin B / administration & dosage
Antifungal Agents / administration & dosage*
Candidiasis / complications*,  drug therapy*
Drug Therapy, Combination
Echinocandins / administration & dosage*
Ichthyosis, Lamellar / complications*
Infant, Newborn
Infant, Premature
Sepsis / complications,  drug therapy
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/caspofungin; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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