| Successful transplantation of cadaver hearts harvested one hour after hypoxic cardiac arrest. | |
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MedLine Citation:
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PMID: 8771508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A shortage of donor organs in clinical transplantation prompted us to study whether resuscitated "dead" hearts could be used for successful orthotopic heart transplantation. METHODS: Donor hearts were resuscitated with cardiopulmonary bypass after 3 minutes (the control group; n = 8) or 60 minutes (the experimental group; n = 6) of hypoxic cardiac arrest after induction of brain death. RESULTS: All the animals of each group were successfully weaned from cardiopulmonary bypass with 5 micrograms/kg/min of dopamine 1 hour after transplantation, and cardiac function with or without dopamine was better preserved in the experimental group than the control group (with maximum slope of pressure-volume relationship with dopamine: 198.0% +/- 36.8% versus 121.2% +/- 47.2%; maximum slope of pressure-volume relationship without dopamine: 130.6% +/- 41.5% versus 70.8% +/- 21.5% [mean +/- standard deviation] as percentage of values after brain death, respectively; p < 0.01 by unpaired t test). CONCLUSIONS: These results indicate that cadaver hearts 60 minutes after anoxic arrest can be successfully reanimated and orthotopically engrafted with various methods and drugs. |
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Authors:
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M Takagaki; K Hisamochi; T Morimoto; K Bando; S Sano; N Shimizu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 15 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 527-31 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Okayama University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia Atrial Function, Left Blood Pressure Brain Death Cadaver* Cardiac Output Cardiac Volume Cardiopulmonary Bypass Dogs Dopamine / therapeutic use Heart Arrest Heart Transplantation* / physiology Organ Preservation Resuscitation Time Factors Tissue and Organ Procurement* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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