Document Detail


Successful transplantation of cadaver hearts harvested one hour after hypoxic cardiac arrest.
MedLine Citation:
PMID:  8771508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A shortage of donor organs in clinical transplantation prompted us to study whether resuscitated "dead" hearts could be used for successful orthotopic heart transplantation. METHODS: Donor hearts were resuscitated with cardiopulmonary bypass after 3 minutes (the control group; n = 8) or 60 minutes (the experimental group; n = 6) of hypoxic cardiac arrest after induction of brain death. RESULTS: All the animals of each group were successfully weaned from cardiopulmonary bypass with 5 micrograms/kg/min of dopamine 1 hour after transplantation, and cardiac function with or without dopamine was better preserved in the experimental group than the control group (with maximum slope of pressure-volume relationship with dopamine: 198.0% +/- 36.8% versus 121.2% +/- 47.2%; maximum slope of pressure-volume relationship without dopamine: 130.6% +/- 41.5% versus 70.8% +/- 21.5% [mean +/- standard deviation] as percentage of values after brain death, respectively; p < 0.01 by unpaired t test). CONCLUSIONS: These results indicate that cadaver hearts 60 minutes after anoxic arrest can be successfully reanimated and orthotopically engrafted with various methods and drugs.
Authors:
M Takagaki; K Hisamochi; T Morimoto; K Bando; S Sano; N Shimizu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  15     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  IM    
Affiliation:
Second Department of Surgery, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia
Atrial Function, Left
Blood Pressure
Brain Death
Cadaver*
Cardiac Output
Cardiac Volume
Cardiopulmonary Bypass
Dogs
Dopamine / therapeutic use
Heart Arrest
Heart Transplantation* / physiology
Organ Preservation
Resuscitation
Time Factors
Tissue and Organ Procurement*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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