Document Detail


Successful transfer of day 10 horse embryos: influence of donor-recipient asynchrony on embryo development.
MedLine Citation:
PMID:  19948839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 78 day 10 horse embryos were transferred non-surgically to recipient mares that had ovulated 9, 7, 6, 5, 4, 3, 2 or 1 day after (negative asynchrony), on the same day (synchronous), or 2 or 4 days before (positive asynchrony) the donor (n=6 or 8 mares per group). Pregnancy rates between 100% (6/6) and 63% (5/8) were seen in recipient mares that were between +2 and -6 days asynchronous. Embryo survival to the heartbeat stage declined in recipients that were -7 days asynchronous and no embryos survived in recipients that were -9 days asynchronous. Irrespective of uterine asynchrony, cessation of embryo mobility and fixation at the base of a uterine horn occurred when the conceptus was approximately 17 days old. Conceptus growth and development was slowed when embryos were placed in negatively asynchronous uteri. At the greatest degree of negative asynchrony at which embryos survived to the heartbeat stage, i.e. -7 and -6 days, development of the embryo proper and allantois was retarded. Luteostasis was achieved in recipient mares when day 10 embryos were transferred to recipient mares at any stage of asynchrony between -9 and +2 days with respect to the donor. These results indicate that in the horse, there is a wide window for establishment of pregnancy following embryo transfer to asynchronous recipients. Although progesterone priming of the uterus to a stage equivalent to that of the transferred embryo does not appear to be a prerequisite for embryo survival, it does nonetheless influence embryonic development.
Authors:
Sandra Wilsher; Amber Clutton-Brock; W R Allen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-11-30
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  139     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  575-85     Citation Subset:  IM    
Affiliation:
The Paul Mellon Laboratory of Equine Reproduction, Newmarket, Suffolk CB8 9DE, UK (formerly The Equine Fertility Unit, Newmarket, Suffolk, UK). paulmellonlab@btconnect.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival
Cleavage Stage, Ovum / cytology,  physiology,  transplantation
Embryo Transfer / methods*,  veterinary
Embryo, Mammalian
Embryonic Development / physiology*
Estrus Synchronization / physiology*
Female
Gestational Age
Horses* / embryology,  physiology
Pregnancy
Pregnancy Rate
Time Factors
Tissue Donors*
Transplantation / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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