| Successful thrombus extraction with the Rescue thrombus management system during acute percutaneous coronary intervention improves flow but does not necessarily restore optimal myocardial tissue perfusion. | |
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MedLine Citation:
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PMID: 16652368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined the effectiveness of the Rescue device in restoring flow and achieving optimal tissue perfusion during percutaneous coronary intervention (PCI) in thrombus-laden coronary arteries. METHODS: A total of 30 patients with an acute coronary syndrome underwent PCI using the Rescue device. RESULTS: The mean age was 65.5 +/- 9.8 years. Although the Rescue device could not be passed across the lesion in 6 (20%) cases, debris was aspirated in 26 (87%). The uncorrected TIMI frame count improved following the use of the Rescue device and improved further at the completion of PCI (92.2 +/- 23.9 pre-PCI vs. 38.7 +/- 31.3 post-Rescue vs. 21.96 +/- 24 post-PCI, P < 0.0001). The thrombus score improved from 4 +/- 0 to 2.2 +/- 1.29 to 0.86 +/- 1.4 (P < 0.0001). TIMI flow grade (TFG) 3 was restored in 60% of cases following the Rescue device and in 87% after PCI. Myocardial blush grade 3 occurred in only 13% of patients following the Rescue device and 37% of patients after PCI. CONCLUSION: These data suggest that the Rescue device can aspirate considerable amounts of debris in the majority of patients and significantly improves the angiographic epicardial coronary blood flow. How effective such a device is in improving tissue perfusion and, thereby, clinical outcomes for patients remains to be seen. |
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Authors:
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Kunadian Vijayalakshmi; Babu Kunadian; Robert A Wright; Andrew G C Sutton; James A Hall; Mark A de Belder |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 67 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-30 Completed Date: 2006-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 879-86 Citation Subset: IM |
Copyright Information:
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Copyright 2006 Wiley-Liss., Inc. |
Affiliation:
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Department of Cardiology, the James Cook University Hospital, Middlesbrough, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Atherectomy, Coronary* / methods Coronary Angiography Coronary Circulation* Coronary Thrombosis / physiopathology, radiography, therapy* Embolism / prevention & control Female Humans Male Myocardial Infarction / physiopathology, radiography, therapy* Myocardial Reperfusion* Stents Treatment Outcome Vascular Patency |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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