Document Detail

Successful therapy of interstitial cystitis with pentosanpolysulfate.
MedLine Citation:
PMID:  2442417     Owner:  NLM     Status:  MEDLINE    
Sodium pentosanpolysulfate (Elmiron) is a synthetic, sulfated polysaccharide available in an oral form that is excreted into the urine. This drug was used in a double-blind fashion to evaluate its efficacy in the management of symptoms of interstitial cystitis. A dose of 100 mg. 3 times daily was used for a minimum of 4 months and was continued for longer than 18 months in some individuals. A total of 62 patients was evaluated from 2 different medical centers. Subjective improvements were greater in all parameters when the drug was compared to placebo therapy, with significant improvement in pain, urgency, frequency and nocturia. Objective improvement in average voided volumes was greater with the drug than with placebo (p equals 0.009). No significant difference was found between drug and placebo groups in the average number of daily voiding episodes.
C L Parsons; S G Mulholland
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  138     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  513-6     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Cystitis / complications,  drug therapy*
Double-Blind Method
Pain / etiology
Pentosan Sulfuric Polyester / therapeutic use*
Polysaccharides / therapeutic use*
Random Allocation
Time Factors
Reg. No./Substance:
0/Polysaccharides; 37300-21-3/Pentosan Sulfuric Polyester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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