| Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis. | |
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MedLine Citation:
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PMID: 12055607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on a patient with primary AL amyloidosis who presented with progressive liver failure secondary to hepatic infiltration in the absence of significant extrahepatic involvement. Orthotopic liver transplantation was performed successfully. After an uneventful postoperative course, the patient developed evidence of significant recurrent amyloidosis requiring treatment. He then underwent stem cell transplantation 10 and 14 months after liver transplantation. After 28 months of follow-up posttransplantation, the patient continues to do well, with no clinical evidence of recurrent disease. This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder. |
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Authors:
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K Shiva Kumar; Jay Lefkowitch; Mark W Russo; Charles Hesdorffer; Milan Kinkhabwala; Sandip Kapur; Jean C Emond; Robert S Brown |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 122 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-10 Completed Date: 2002-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 2026-31 Citation Subset: AIM; IM |
Affiliation:
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Center for Liver Disease and Transplantation, New York-Presbyterian Hospital, New York 10036, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amyloidosis / classification, complications*, pathology, surgery* Hematopoietic Stem Cell Transplantation* Humans Liver / pathology Liver Failure / etiology*, pathology, surgery* Liver Transplantation* Male Treatment Outcome |
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