| Successful salvage chemotherapy for isolated central nervous system (CNS) relapse in Burkitt lymphoma: monocentric experience of 3 pediatric patients. | |
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MedLine Citation:
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PMID: 19131795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short-term intensive chemotherapy regimens have substantially improved the prognosis of pediatric patients with Burkitt lymphoma (BL), which now has an excellent overall outcome. However, central nervous system (CNS) involvement at diagnosis remains a poor prognostic factor, and progressive or relapsed disease in the CNS is associated with even worse outcomes. We report 3 boys aged 4, 7, and 12 years treated under the French Société Française d'Oncologie Pédiatrique LMB 89/96 protocols who presented, respectively, with CNS-/bone marrow+ stage-IV BL; CNS+ stage-IV BL; and stage-I BL. Each experienced an isolated CNS relapse, which was treated with CNS-directed salvage chemotherapy. All 3 are alive after 11 years of median follow-up, indicating that this chemotherapy regimen can be curative in pediatric BL with isolated CNS relapse. |
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Authors:
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Frederic Baleydier; Corinne Pondarre; Marie-Pierre Pages; Valerie Mialou; Kamila Kebaili; Jean-Pierre Pracros; Yves Bertrand |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 30 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-02-03 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 972-5 Citation Subset: IM |
Affiliation:
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Pediatric Immunology and Hematology Department, Institut d'Hématologie et Oncologie Pédiatrique, France. fbaleydier@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use* Burkitt Lymphoma / drug therapy*, pathology Central Nervous System Neoplasms / drug therapy*, pathology Child Child, Preschool Cyclophosphamide / therapeutic use Cytarabine / therapeutic use Humans Magnetic Resonance Imaging Male Methotrexate / therapeutic use Neoplasm Recurrence, Local / drug therapy*, pathology Remission Induction Salvage Therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 50-18-0/Cyclophosphamide; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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