| Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis. | |
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MedLine Citation:
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PMID: 22360400 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ekong UD, Mathew J, Melin-Aldana H, Wang D, Alonso EM. Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis. Pediatr Transplantation 2012: 16: 165-175. © 2012 John Wiley & Sons A/S. Abstract: This retrospective case series reviews our center's experience with sirolimus and a CNI as alternative therapy for the treatment of PTAH. It also characterizes regulatory T cells (Tregs) in PTAH. LT recipients with PTAH who had received or were receiving treatment with sirolimus were retrospectively identified (n = 12). Liver enzymes, immunohistochemistry, and histology were compared in all 12 patients. Immunophenotyping for Tregs in peripheral blood mononuclear cells was performed on LT recipients with PTAH on conventional therapy with CNI, azathioprine ± prednisone (CT) (n = 11), recipients with PTAH on sirolimus, CNI ± prednisone (n = 8), recipients without PTAH (n = 25), and pre-transplant patients (n = 5). Severity of necro-inflammatory changes markedly improved with sirolimus. Treg frequency and number were significantly lower in recipients with PTAH on CT compared to (i) those on sirolimus (p = 0.002 and p = 0.01, respectively), and (ii) recipients without PTAH (p = 0.07 and p = 0.009, respectively). Treg frequency was significantly higher in recipients with PTAH on sirolimus compared to recipients without PTAH under CNI therapy (p = 0.027). Sirolimus in addition to a CNI is successful in reversing inflammation in LT recipients with PTAH. This is associated with significantly higher circulating Tregs. |
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Authors:
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Udeme D Ekong; James Mathew; Hector Melin-Aldana; Deli Wang; Estella M Alonso |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric transplantation Volume: 16 ISSN: 1399-3046 ISO Abbreviation: Pediatr Transplant Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9802574 Medline TA: Pediatr Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 165-75 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Siragusa Transplant Center, Children's Memorial Hospital Comprehensive Transplant Center, Department of Surgery, Northwestern University Department of Microbiology-Immunology, Northwestern University Department of Pathology, Children's Memorial Hospital Children's Memorial Research Center, Chicago, IL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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