| Successful rescue of an early interstitial pregnancy after failed systemic methotrexate treatment: a case report. | |
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MedLine Citation:
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PMID: 17506378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Interstitial (cornual) pregnancy is a rare and life-threatening disease. Although systemic treatment with methotrexate (MTX) in an unruptured interstitial pregnancy has been used to preserve the entirety of the uterus, surgery is often used as a rescue method in failed cases. Use of an ultrasound-guided local injection can be a good alternative to surgery. CASE: A 30-year-old woman, gravida 1, para 0, with an interstitial pregnancy at 10 weeks of gestation, was successfully treated with an ultrasound-guided 100-mg MTX injection after a failed response to 3-dose intramuscular 100-mg MTX treatment (300 mg in total). Regular menstruation occurred 1 month after the local MTX injection. The serum beta-human chorionic gonadotropin level was undetectable 49 days later, and the residual mass had disappeared 6 months later, CONCLUSION: Local injection of MTX may be a good means of managing an unruptured interstitial pregnancy to preserve the entirety of the uterus after failed systemic MTX treatment. Use of a local MTX injection may be a better choice than that of systemic MTX treatment. |
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Authors:
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Yu-Shiou Lin; Cheng-Li Chen; Chiou-Chung Yuan; Peng-Hui Wang |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 52 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-05-17 Completed Date: 2007-06-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 332-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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therapeutic use* Adult Female Humans Injections, Intramuscular Methotrexate / therapeutic use* Pregnancy Pregnancy, Ectopic / drug therapy* Treatment Failure Treatment Outcome Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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