Document Detail

Successful rescue of an early interstitial pregnancy after failed systemic methotrexate treatment: a case report.
MedLine Citation:
PMID:  17506378     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interstitial (cornual) pregnancy is a rare and life-threatening disease. Although systemic treatment with methotrexate (MTX) in an unruptured interstitial pregnancy has been used to preserve the entirety of the uterus, surgery is often used as a rescue method in failed cases. Use of an ultrasound-guided local injection can be a good alternative to surgery. CASE: A 30-year-old woman, gravida 1, para 0, with an interstitial pregnancy at 10 weeks of gestation, was successfully treated with an ultrasound-guided 100-mg MTX injection after a failed response to 3-dose intramuscular 100-mg MTX treatment (300 mg in total). Regular menstruation occurred 1 month after the local MTX injection. The serum beta-human chorionic gonadotropin level was undetectable 49 days later, and the residual mass had disappeared 6 months later, CONCLUSION: Local injection of MTX may be a good means of managing an unruptured interstitial pregnancy to preserve the entirety of the uterus after failed systemic MTX treatment. Use of a local MTX injection may be a better choice than that of systemic MTX treatment.
Yu-Shiou Lin; Cheng-Li Chen; Chiou-Chung Yuan; Peng-Hui Wang
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  52     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use*
Injections, Intramuscular
Methotrexate / therapeutic use*
Pregnancy, Ectopic / drug therapy*
Treatment Failure
Treatment Outcome
Ultrasonography, Interventional
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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