| Successful pulmonary thromboendarterectomy in two patients with sickle cell disease. | |
| | |
MedLine Citation:
|
PMID: 9603156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Patients with sickle cell disease have been reported to have an increased risk of thromboembolism and pulmonary hypertension. Some of these patients may benefit from pulmonary thromboendarterectomy (PTE), a procedure that requires profound hypothermia, cardiopulmonary bypass, and periods of circulatory arrest, factors that may potentially increase the risk of sickling. Two patients with sickle cell disease (sickle-thalassemia [Hb S/beta+] and Hb SS) presented to the Pulmonary Vascular Center of UCSD Medical Center with significant shortness of breath and limitation of daily activities. Both of these patients were found to have surgically accessible chronic thromboembolic disease with pulmonary hypertension. PTE was performed in both patients using exchange transfusion, with avoidance of anemia, hypoxia, and acidosis. A successful outcome with resolution of pulmonary hypertension was achieved in both cases. To our knowledge this is the first report of patients with sickle cell disease who successfully underwent PTE for chronic thromboembolic pulmonary hypertension. |
| | |
Authors:
|
G L Yung; R N Channick; P F Fedullo; W R Auger; K M Kerr; S W Jamieson; D P Kapelanski; K M Moser |
Related Documents
:
|
6663606 - Phagocytosis in patients with sickle cell disease. 9529466 - Compliance with penicillin prophylaxis in patients with sickle cell disease. 2391596 - Variable clinical severity of hereditary spherocytosis: relation to erythrocytic spectr... 10590046 - Increased incidence of cytomegalovirus disease after autologous cd34-selected periphera... 10502576 - Ocular manifestations in children and adolescents with lyme arthritis. 21562726 - Prognostic value of adenosine stress cardiovascular magnetic resonance and dobutamine s... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 157 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1998 May |
Date Detail:
|
Created Date: 1998-06-16 Completed Date: 1998-06-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1690-3 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, University of California at San Diego, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anemia, Sickle Cell / complications*, therapy Chronic Disease Endarterectomy* Exchange Transfusion, Whole Blood Female Humans Male Postoperative Complications Preoperative Care Pulmonary Artery / surgery Pulmonary Embolism / etiology, pathology, surgery* beta-Thalassemia / complications*, therapy |
| Grant Support | |
ID/Acronym/Agency:
|
5T32 HL-07022-22/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fatal air embolism in an airplane passenger with a giant intrapulmonary bronchogenic cyst.
Next Document: Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease.