Document Detail


Successful pulmonary thromboendarterectomy in two patients with sickle cell disease.
MedLine Citation:
PMID:  9603156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with sickle cell disease have been reported to have an increased risk of thromboembolism and pulmonary hypertension. Some of these patients may benefit from pulmonary thromboendarterectomy (PTE), a procedure that requires profound hypothermia, cardiopulmonary bypass, and periods of circulatory arrest, factors that may potentially increase the risk of sickling. Two patients with sickle cell disease (sickle-thalassemia [Hb S/beta+] and Hb SS) presented to the Pulmonary Vascular Center of UCSD Medical Center with significant shortness of breath and limitation of daily activities. Both of these patients were found to have surgically accessible chronic thromboembolic disease with pulmonary hypertension. PTE was performed in both patients using exchange transfusion, with avoidance of anemia, hypoxia, and acidosis. A successful outcome with resolution of pulmonary hypertension was achieved in both cases. To our knowledge this is the first report of patients with sickle cell disease who successfully underwent PTE for chronic thromboembolic pulmonary hypertension.
Authors:
G L Yung; R N Channick; P F Fedullo; W R Auger; K M Kerr; S W Jamieson; D P Kapelanski; K M Moser
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  157     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-16     Completed Date:  1998-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1690-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of California at San Diego, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / complications*,  therapy
Chronic Disease
Endarterectomy*
Exchange Transfusion, Whole Blood
Female
Humans
Male
Postoperative Complications
Preoperative Care
Pulmonary Artery / surgery
Pulmonary Embolism / etiology,  pathology,  surgery*
beta-Thalassemia / complications*,  therapy
Grant Support
ID/Acronym/Agency:
5T32 HL-07022-22/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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