Document Detail

Successful prevention of thrombotic thrombocytopenic purpura (TTP) relapse using monthly prophylactic plasma exchanges throughout pregnancy in a patient with systemic lupus erythematosus and a prior history of refractory TTP and recurrent fetal loss.
MedLine Citation:
PMID:  20547472     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The occurrence of thrombotic thrombocytopenic purpura (TTP) in the setting systemic lupus erythematosus (SLE) is rare. In women of childbearing age, TTP is associated with high rates of recurrence in pregnancy. Furthermore, both TTP and SLE are associated with a significant risk of adverse pregnancy outcomes.
CASE PRESENTATION: We describe the case of a 36 year old female in her first trimester of pregnancy with a prior history of SLE-associated severe refractory TTP who was treated with a combination of corticosteroids and prophylactic plasma exchanges (PLEX) throughout pregnancy to prevent TTP recurrence. She delivered a healthy infant at 33 weeks of gestation after the onset of preterm labor. There was no evidence of TTP recurrence in the antepartum or postpartum period in this high risk patient.
CONCLUSION: Prophylactic PLEX should be considered as a therapeutic option to prevent recurrent TTP during pregnancy in high risk patients, including patients with previous SLE-associated TTP.
Karim Abou-Nassar; Jacob Karsh; Antonio Giulivi; David Allan
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-06-14
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  43     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-31     Citation Subset:  T    
Copyright Information:
(c) 2010 Elsevier Ltd. All rights reserved.
Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada.
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MeSH Terms
Abortion, Habitual / etiology,  prevention & control*
Chronic Disease
Lupus Erythematosus, Systemic / blood,  complications*,  therapy
Plasma Exchange
Pregnancy Complications, Hematologic / drug therapy,  prevention & control*
Purpura, Thrombotic Thrombocytopenic / drug therapy,  prevention & control*

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