Document Detail

Successful pregnancy in a woman with a human seminal plasma allergy. A case report.
MedLine Citation:
PMID:  10319315     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human seminal plasma allergy is an anaphylaxis caused by immediate hypersensitivity to human seminal plasma. The utilization of a condom is usually recommended as the primary means of preventing an allergic reaction. Infertility resulting from condom use, however, is an undesirable complication in many cases. Here we report on a successfully established pregnancy in a woman with seminal plasma allergy. CASE: A 29-year-old, married nulligravida with a human seminal plasma allergy consulted us to conceive. She showed a positive reaction to a skin-prick test with whole semen. In order to remove the seminal plasma, the sperm were washed three times using a continuous-step density gradient centrifugation method. Artificial insemination with the washed sperm was performed without anaphylactic symptoms. After six inseminations, pregnancy was achieved, and a healthy infant was delivered. CONCLUSION: Artificial insemination with sperm devoid of seminal plasma was very useful for establishing pregnancy in a woman with a human seminal plasma allergy.
K Iwahashi; T Miyazaki; N Kuji; Y Yoshimura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  44     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-29     Completed Date:  1999-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Anaphylaxis / diagnosis,  etiology*,  immunology,  prevention & control*
Insemination, Artificial, Homologous* / methods
Pregnancy Outcome*
Semen / immunology*
Skin Tests

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