| Successful pregnancy in a patient with chronic myeloid leukemia under treatment with imatinib. | |
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MedLine Citation:
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PMID: 19687593 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Contraception is recommended during imatinib therapy based on the teratogenicity data in rats. However, patients may become pregnant and here we describe a successful pregnancy and labor without any congenital anomaly in a patient with chronic myeloid leukemia (CML) under treatment with imatinib. The patient had received imatinib for 53 months before she became pregnant, with a complete cytogenetic response achieved after 6 months of therapy and a major molecular response (MMR) after 28 months. CML was in MMR at discovery of pregnancy and the fetus had been exposed to imatinib for 5 weeks. Treatment was discontinued, but MMR persisted during gestation. |
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Authors:
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Motohiro Tsuzuki; Youko Inaguma; Kousuke Handa; Akio Hasegawa; Yukiya Yamamoto; Masato Watanabe; Syuichi Mizuta; Fumio Maruyama; Masataka Okamoto; Nobuhiko Emi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-17 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1433-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Fujita Health University, School of Medicine, Toyoake. mtsuzuki@fujita-hu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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