| Successful pregnancy following oocyte activation by strontium in normozoospermic patients of unexplained infertility with fertilisation failures during previous intracytoplasmic sperm injection treatment. | |
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MedLine Citation:
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PMID: 20450837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fertilisation failures occur in 2-3% of intracytoplasmic sperm injection (ICSI) cycles and are mostly caused by failure of oocyte activation. Assisted oocyte activation (AOA) may be an efficient treatment option to overcome oocyte activation failure. To evaluate the effectiveness of ICSI combined with AOA by strontium, six couples with complete fertilisation failure or low fertilisation rates (ranging from 0% to 16.7%; mean = 7.7%) in previous ICSI cycles were involved in the present study. In the latest ICSI cycles, AOA by strontium treatment was combined with ICSI to improve clinical outcomes. Fifty-two mature oocytes retrieved from six females were stimulated by strontium treatment after ICSI procedure, and 41 (78.8%) of them were successfully fertilised. The high-quality embryo rate was 41.5% (17/41) after culture for 5 days. Thirteen embryos were transferred (ranging from 2 to 3 per individual) resulting in three clinical pregnancies and three healthy babies were born. Furthermore, a pregnancy resulting in the birth of a healthy female infant was achieved following transfer of three frozen-thawed embryos. In conclusion, it appears that strontium treatment would be an effective method for AOA to improve fertilisation rates and embryo quality in cases with fertilisation failure after ICSI. |
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Authors:
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Juan Chen; Yun Qian; Yong Tan; Hirofumi Mima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproduction, fertility, and development Volume: 22 ISSN: 1031-3613 ISO Abbreviation: Reprod. Fertil. Dev. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907465 Medline TA: Reprod Fertil Dev Country: Australia |
Other Details:
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Languages: eng Pagination: 852-5 Citation Subset: IM |
Affiliation:
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Department of Reproductive Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cryopreservation Embryo Culture Techniques Female Humans Infertility / therapy* Male Oocytes / drug effects*, physiology* Pregnancy Pregnancy Rate Sperm Injections, Intracytoplasmic / methods* Strontium / pharmacology* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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7440-24-6/Strontium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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